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Cryo-EM structure of dengue virus serotype 1 strain westpac 74 in complex with human antibody 1C19 Fab at 37 deg C (class 1 particle)
Analyse Cryo-EM structure of dengue virus serotype 1 strain westpac 74 in complex with… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7DWT
- Type
- protein
- Length
- 1,408 residues
- Chains
- 5
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Envelope protein; Anti-dengue virus human monoclonal antibody 1C19 Fab heavy chain…
- Pockets
- 2 · best druggability 0.38
Structure
electron microscopy · 3 distinct chains · 0% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C | Envelope protein | protein | 394 | 0% helix, 0% strand | — |
| H | Anti-dengue virus human monoclonal antibody 1C19 Fab heavy chain | protein | 120 | 0% helix, 0% strand | — |
| L | Anti-dengue virus human monoclonal antibody 1C19 Fab light chain | protein | 106 | 0% helix, 0% strand | — |
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 102 | 0.38 | 0.73 | 28 | empty |
| 2 | 94 | 0.36 | 0.73 | 27 | empty |
Interfaces
4 interfaces between chains.
- A–B · 219 Ų buried · 0 hydrogen bonds · protein-protein
- A–C · 195 Ų buried · 0 hydrogen bonds · protein-protein
- H–L · 71 Ų buried · 0 hydrogen bonds · protein-protein
- A–L · 25 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 7DWT · Cryo-EM structure of Dengue virus serotype 1 strain WestPac 74 in complex with human… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 7DWT · PDBe 7DWT
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