Research workbench

SARS-cov-2 mpro mutant (H41A) in complex with NSP15|16 peptidyl substrate

Analyse SARS-cov-2 mpro mutant (H41A) in complex with NSP15|16 peptidyl substrate in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 7DW0
Type: protein
Length: 308 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: 3C-like proteinase; NSP15/16 peptidyl substrate
EC: 3.4.22.69
UniProt: P0DTD1
Pockets: 1 · best druggability 0.36

Structure

x-ray diffraction · 2 distinct chains · 25% helix, 29% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	3C-like proteinase (EC 3.4.22.69)	protein	300	26% helix, 29% strand	P0DTD1
C	NSP15/16 peptidyl substrate	protein	8	0% helix, 25% strand	P0DTD1

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	98	0.36	0.74	21	empty

Interfaces

1 interface between chains.

A–C · 771 Å² buried · 21 hydrogen bonds · protein-protein

Compared structures

7DW0 · SARS-CoV-2 Mpro mutant (H41A) in complex with nsp14|15 peptidyl substrate · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P0DTD1
Elsewhere: RCSB PDB 7DW0 · PDBe 7DW0 · UniProt P0DTD1

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.