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The structure of the M.TB mazf-MT1 toxin in complex with a fragment of cognate antitoxin

Analyse The structure of the M.TB mazf-MT1 toxin in complex with a fragment of cognate… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 7DU5
Type: protein
Length: 250 residues
Chains: 3
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Endoribonuclease MAZF9; A fragment of maze-MT1
EC: 3.1.-.-
UniProt: P71650
Pockets: 1 · best druggability 0.39

Structure

x-ray diffraction · 3 distinct chains · 32% helix, 31% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Endoribonuclease MAZF9 (EC 3.1.-.-)	protein	117	30% helix, 33% strand	P71650
B	Endoribonuclease MAZF9 (EC 3.1.-.-)	protein	118	29% helix, 33% strand	P71650
C	A fragment of maze-MT1	protein	15	67% helix, 0% strand	—

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	108	0.39	0.75	21	empty

Interfaces

3 interfaces between chains.

A–B · 1572 Å² buried · 37 hydrogen bonds · protein-protein
A–C · 604 Å² buried · 7 hydrogen bonds · protein-protein
B–C · 378 Å² buried · 1 hydrogen bond · protein-protein

Compared structures

7DU5 · The structure of the M.tb MazF-mt1 toxin in complex with a fragment of cognate antitoxin · the same entry in another collection · chain A against A, TM-score 1.00
P71650 · AlphaFold monomer V2.0 prediction for endoribonuclease MAZF9 (P71650) · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P71650
Elsewhere: RCSB PDB 7DU5 · PDBe 7DU5 · UniProt P71650

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