Research workbench
Structural insights into viral RNA capping and plasma membrane targeting by chikungunya virus nonstructural protein 1
Analyse Structural insights into viral RNA capping and plasma membrane targeting by… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7DOP
- Type
- protein
- Length
- 5,352 residues
- Chains
- 12
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Nonstructural protein 1
- UniProt
- Q8JUX6
- Ligands
- ZN
- Pockets
- 20 · best druggability 0.84
Structure
electron microscopy · 1 distinct chain · 30% helix, 27% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E, F, G, H, I, J, K, L | Nonstructural protein 1 | protein | 446 | 30% helix, 27% strand | Q8JUX6 |
Ligands and binding sites
- ZN · Zinc ion · metal · 12 copies · chains A, B, C, D, E, F, G, H, I, J, K, L
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 904 | 0.84 | 0.86 | 116 | empty |
| 2 | 909 | 0.84 | 0.86 | 116 | empty |
| 3 | 341 | 0.84 | 0.93 | 50 | empty |
| 4 | 329 | 0.84 | 0.93 | 46 | empty |
| 5 | 907 | 0.84 | 0.85 | 117 | empty |
Interfaces
24 interfaces between chains.
- K–L · 3205 Ų buried · 37 hydrogen bonds · protein-protein
- J–L · 3203 Ų buried · 35 hydrogen bonds · protein-protein
- I–K · 3199 Ų buried · 35 hydrogen bonds · protein-protein
- A–B · 3191 Ų buried · 38 hydrogen bonds · protein-protein
- A–J · 3190 Ų buried · 33 hydrogen bonds · protein-protein
Compared structures
- 7DOP · Structural insights into viral RNA capping and plasma membrane targeting by Chikungunya… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8JUX6
- Elsewhere: RCSB PDB 7DOP · PDBe 7DOP · UniProt Q8JUX6
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.