Research workbench
Mouse radial spoke complex
Analyse Mouse radial spoke complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7DMP
- Type
- protein
- Length
- 1,528 residues
- Chains
- 6
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Radial spoke head protein 4 homolog a; Radial spoke head 1 homolog; Radial spoke head…
- UniProt
- Q8BYM7, Q8VIG3, Q9D9V4
- Pockets
- 19 · best druggability 0.87
Structure
electron microscopy · 3 distinct chains · 14% helix, 25% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| B, b | Radial spoke head protein 4 homolog a | protein | 336 | 18% helix, 15% strand | Q8BYM7 |
| A, a | Radial spoke head 1 homolog | protein | 186 | 0% helix, 55% strand | Q8VIG3 |
| C, c | Radial spoke head protein 9 homolog | protein | 242 | 19% helix, 17% strand | Q9D9V4 |
Pockets
19 pockets found on a 1 Å grid, 13 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1153 | 0.87 | 0.88 | 142 | empty |
| 2 | 501 | 0.74 | 0.83 | 73 | empty |
| 3 | 623 | 0.73 | 0.80 | 80 | empty |
| 4 | 469 | 0.72 | 0.81 | 67 | empty |
| 5 | 426 | 0.70 | 0.81 | 57 | empty |
Interfaces
10 interfaces between chains.
- B–A · 2204 Ų buried · 16 hydrogen bonds · protein-protein
- b–a · 2170 Ų buried · 18 hydrogen bonds · protein-protein
- B–C · 1936 Ų buried · 35 hydrogen bonds · protein-protein
- b–c · 1806 Ų buried · 31 hydrogen bonds · protein-protein
- B–b · 902 Ų buried · 11 hydrogen bonds · protein-protein
Compared structures
- 7DMP · Mouse radial spoke complex · the same entry in another collection · chain c against c, TM-score 1.00
- Q8BYM7 · AlphaFold monomer V2.0 prediction for radial spoke head protein 4 homolog a (Q8BYM7) · a predicted model of the same protein · chain B against A, TM-score 0.96
- Q9D9V4 · AlphaFold monomer V2.0 prediction for radial spoke head protein 9 homolog (Q9D9V4) · a predicted model of the same protein · chain C against A, TM-score 0.95
- Q8VIG3 · AlphaFold monomer V2.0 prediction for radial spoke head 1 homolog (Q8VIG3) · a predicted model of the same protein · chain A against A, TM-score 0.93
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8BYM7
- Every structure of UniProt Q8VIG3
- Every structure of UniProt Q9D9V4
- Elsewhere: RCSB PDB 7DMP · PDBe 7DMP · UniProt Q8BYM7 · UniProt Q8VIG3 · UniProt Q9D9V4
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.