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NMR solution structure of the 1:1 complex of a PLATINUM(II) compound bound to 3'-end of MYC1234 G-quadruplex reveals the mechanism of conformational switch and dynamic binding of G-quadruplex

Analyse NMR solution structure of the 1:1 complex of a PLATINUM(II) compound bound to… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 7DJW
Type: DNA
Length: 19 nucleotides
Chains: 1
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: MYC1234 G-quadruplex DNA (5'- D(*TP*AP*GP*GP*GP*AP*GP*GP*GP*TP*AP*GP*GP*GP*AP*GP*GP*GP*T)…
Ligands: H9C
Pockets: 1 · best druggability 0.28

Structure

solution nmr · 1 distinct chain.

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	MYC1234 G-quadruplex DNA (5'- D(TPAPGPGPGPAPGPGPGPTPAPGPGPGPAPGPGPGP*T)-3')	dna	19	—	—

Ligands and binding sites

H9C · Bis(1,10-phenanthroline)platinum(ii) · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	71	0.28	0.73	7	H9C

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 7DJW · PDBe 7DJW

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