Research workbench
Crystal structure of SARS-cov-2 ORF9B complex with human TOM70
Analyse Crystal structure of SARS-cov-2 ORF9B complex with human TOM70 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7DHG
- Type
- protein
- Length
- 506 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Mitochondrial import receptor subunit TOM70; ORF9B protein
- UniProt
- O94826, P0DTD2
- Pockets
- 4 · best druggability 0.79
Structure
x-ray diffraction · 2 distinct chains · 77% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| C | Mitochondrial import receptor subunit TOM70 | protein | 470 | 78% helix, 0% strand | O94826 |
| B | ORF9B protein | protein | 36 | 67% helix, 0% strand | P0DTD2 |
Pockets
4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 614 | 0.79 | 0.84 | 78 | empty |
| 2 | 323 | 0.71 | 0.84 | 30 | empty |
| 3 | 69 | 0.35 | 0.77 | 13 | empty |
| 4 | 55 | 0.32 | 0.76 | 11 | empty |
Interfaces
1 interface between chains.
- C–B · 2045 Ų buried · 16 hydrogen bonds · protein-protein
Compared structures
- 7DHG · Crystal structure of SARS-CoV-2 Orf9b complex with human TOM70 · the same entry in another collection · chain C against C, TM-score 1.00
- O94826 · AlphaFold monomer V2.0 prediction for mitochondrial import receptor subunit TOM70 (O94826) · a predicted model of the same protein · chain C against A, TM-score 0.93
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O94826
- Every structure of UniProt P0DTD2
- Elsewhere: RCSB PDB 7DHG · PDBe 7DHG · UniProt O94826 · UniProt P0DTD2
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