Research workbench

Apo state of class C GPCR

Analyse Apo state of class C GPCR in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 7DGD
Type: protein
Length: 1,572 residues
Chains: 2
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Metabotropic glutamate receptor 1
UniProt: Q13255
Pockets: 20 · best druggability 0.84

Structure

electron microscopy · 1 distinct chain · 42% helix, 10% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Metabotropic glutamate receptor 1	protein	786	42% helix, 10% strand	Q13255

Pockets

20 pockets found on a 1 Å grid, 13 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	272	0.84	0.95	41	empty
2	391	0.81	0.89	51	empty
3	82	0.74	0.97	25	empty
4	286	0.74	0.86	48	empty
5	76	0.73	0.97	23	empty

Interfaces

1 interface between chains.

A–B · 1282 Å² buried · 11 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 17 disulfide (disulfide).

Compared structures

7DGD · apo state of class C GPCR · the same entry in another collection · chain A against A, TM-score 1.00
Q13255 · AlphaFold monomer V2.0 prediction for metabotropic glutamate receptor 1 (Q13255) · a predicted model of the same protein · chain A against A, TM-score 0.85

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q13255
Elsewhere: RCSB PDB 7DGD · PDBe 7DGD · UniProt Q13255

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