Research workbench
Cryo-EM structure of the pre-mRNA-loaded deah-box ATPASE/HELICASE PRP2 in complex with SPP2
Analyse Cryo-EM structure of the pre-mRNA-loaded deah-box ATPASE/HELICASE PRP2 in… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7DD3
- Type
- protein + RNA
- Length
- 734 residues
- Chains
- 3
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- PRP2 isoform 1; Pre-mRNA-splicing factor SPP2; Pre-mRNA
- UniProt
- A0A6A5Q5S8, A0A6A5Q6Y7
- Pockets
- 11 · best druggability 0.88
Structure
electron microscopy · 3 distinct chains · 39% helix, 16% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| x | PRP2 isoform 1 | protein | 653 | 40% helix, 17% strand | A0A6A5Q5S8 |
| y | Pre-mRNA-splicing factor SPP2 | protein | 73 | 27% helix, 0% strand | A0A6A5Q6Y7 |
| G | Pre-mRNA | rna | 8 | — | — |
Pockets
11 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1034 | 0.88 | 0.90 | 118 | empty |
| 2 | 254 | 0.66 | 0.83 | 27 | empty |
| 3 | 116 | 0.65 | 0.89 | 27 | empty |
| 4 | 257 | 0.59 | 0.79 | 30 | empty |
| 5 | 203 | 0.55 | 0.79 | 26 | empty |
Interfaces
2 interfaces between chains.
- x–y · 1759 Ų buried · 12 hydrogen bonds · protein-protein
- x–G · 1230 Ų buried · 23 hydrogen bonds · protein-nucleic
Compared structures
- 7DD3 · Cryo-EM structure of the pre-mRNA-loaded DEAH-box ATPase/helicase Prp2 in complex with… · the same entry in another collection · chain x against x, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A6A5Q5S8
- Every structure of UniProt A0A6A5Q6Y7
- Elsewhere: RCSB PDB 7DD3 · PDBe 7DD3 · UniProt A0A6A5Q5S8 · UniProt A0A6A5Q6Y7
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.