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PNPA1, the oxygenase component of a two-component para-nitrophenol hydroxylase from rhodococcus imtechensis RKJ300

Analyse PNPA1, the oxygenase component of a two-component para-nitrophenol hydroxylase… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 7DBW
Type: protein
Length: 1,494 residues
Chains: 3
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: 4-hydroxyphenylacetate 3-hydroxylase
UniProt: I0WZP1
Pockets: 13 · best druggability 0.69

Structure

x-ray diffraction · 1 distinct chain · 51% helix, 14% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
C, A, B	4-hydroxyphenylacetate 3-hydroxylase	protein	498	51% helix, 14% strand	I0WZP1

Pockets

13 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	491	0.69	0.79	53	empty
2	543	0.68	0.78	53	empty
3	460	0.67	0.79	49	empty
4	246	0.58	0.79	25	empty
5	318	0.57	0.76	27	empty

Interfaces

2 interfaces between chains.

A–B · 3457 Å² buried · 31 hydrogen bonds · protein-protein
C–A · 209 Å² buried · 2 hydrogen bonds · protein-protein

Compared structures

7DBW · PnpA1, the oxygenase component of a two-component para-nitrophenol hydroxylase from… · the same entry in another collection · chain C against C, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt I0WZP1
Elsewhere: RCSB PDB 7DBW · PDBe 7DBW · UniProt I0WZP1

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