Research workbench
Mouse toll-like receptor 3 ectodomain in complex with lncrna rmrp in elongated form
Analyse Mouse toll-like receptor 3 ectodomain in complex with lncrna rmrp in elongated… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7DA7
- Type
- protein + RNA
- Length
- 1,428 residues
- Chains
- 3
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Toll-like receptor 3; RNA component of mitochondrial rnaase P (rmrp), RNase mrp RNA
- UniProt
- Q99MB1
- Pockets
- 3 · best druggability 0.67
Structure
electron microscopy · 2 distinct chains · 10% helix, 17% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Toll-like receptor 3 | protein | 669 | 10% helix, 17% strand | Q99MB1 |
| C | RNA component of mitochondrial rnaase P (rmrp), RNase mrp RNA | rna | 90 | — | — |
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 799 | 0.67 | 0.75 | 71 | empty |
| 2 | 137 | 0.42 | 0.75 | 21 | empty |
| 3 | 114 | 0.40 | 0.76 | 22 | empty |
Interfaces
3 interfaces between chains.
- A–C · 1121 Ų buried · 23 hydrogen bonds · protein-nucleic
- B–C · 1118 Ų buried · 28 hydrogen bonds · protein-nucleic
- A–B · 628 Ų buried · 11 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 8 disulfide (disulfide).
Compared structures
- 7DA7 · Mouse Toll-like receptor 3 ectodomain in complex with lncRNA Rmrp in elongated form · the same entry in another collection · chain A against A, TM-score 1.00
- Q99MB1 · AlphaFold monomer V2.0 prediction for toll-like receptor 3 (Q99MB1) · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q99MB1
- Elsewhere: RCSB PDB 7DA7 · PDBe 7DA7 · UniProt Q99MB1
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