Research workbench
The crystal structure of the chicken fancm-mhf complex
Analyse The crystal structure of the chicken fancm-mhf complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7DA2
- Type
- protein
- Length
- 469 residues
- Chains
- 5
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Centromere protein S; Centromere protein X; Fanconi anemia group M protein
- EC
- 3.6.4.13
- UniProt
- E1BSW7, P0DJH7, A0A1D5PRR9
- Pockets
- 6 · best druggability 0.73
Structure
x-ray diffraction · 5 distinct chains · 65% helix, 5% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Centromere protein S | protein | 96 | 75% helix, 4% strand | E1BSW7 |
| C | Centromere protein S | protein | 92 | 79% helix, 4% strand | E1BSW7 |
| B | Centromere protein X | protein | 75 | 72% helix, 5% strand | P0DJH7 |
| D | Centromere protein X | protein | 74 | 73% helix, 5% strand | P0DJH7 |
| E | Fanconi anemia group M protein (EC 3.6.4.13) | protein | 132 | 40% helix, 5% strand | A0A1D5PRR9 |
Pockets
6 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 650 | 0.73 | 0.80 | 53 | empty |
| 2 | 252 | 0.60 | 0.80 | 27 | empty |
| 3 | 121 | 0.55 | 0.83 | 19 | empty |
| 4 | 80 | 0.53 | 0.86 | 15 | empty |
| 5 | 80 | 0.36 | 0.76 | 17 | empty |
Interfaces
10 interfaces between chains.
- C–D · 2436 Ų buried · 19 hydrogen bonds · protein-protein
- A–B · 2301 Ų buried · 23 hydrogen bonds · protein-protein
- C–E · 1893 Ų buried · 18 hydrogen bonds · protein-protein
- B–E · 1250 Ų buried · 22 hydrogen bonds · protein-protein
- A–E · 1220 Ų buried · 13 hydrogen bonds · protein-protein
Compared structures
- 7DA2 · The crystal structure of the chicken FANCM-MHF complex · the same entry in another collection · chain E against E, TM-score 1.00
- E1BSW7 · AlphaFold monomer V2.0 prediction for centromere protein S (E1BSW7) · a predicted model of the same protein · chain C against A, TM-score 0.98
- P0DJH7 · AlphaFold monomer V2.0 prediction for centromere protein X (P0DJH7) · a predicted model of the same protein · chain D against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt E1BSW7
- Every structure of UniProt P0DJH7
- Every structure of UniProt A0A1D5PRR9
- Elsewhere: RCSB PDB 7DA2 · PDBe 7DA2 · UniProt E1BSW7 · UniProt P0DJH7 · UniProt A0A1D5PRR9
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