Research workbench
Crystal structure of the chicken mhf complex
Analyse Crystal structure of the chicken mhf complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7DA1
- Type
- protein
- Length
- 338 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Centromere protein S; Centromere protein X
- UniProt
- E1BSW7, P0DJH7
- Pockets
- 3 · best druggability 0.34
Structure
x-ray diffraction · 3 distinct chains · 76% helix, 5% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| B | Centromere protein S | protein | 96 | 79% helix, 4% strand | E1BSW7 |
| C, D | Centromere protein X | protein | 75 | 71% helix, 5% strand | P0DJH7 |
| A | Centromere protein S | protein | 92 | 77% helix, 4% strand | E1BSW7 |
Pockets
3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 71 | 0.34 | 0.76 | 18 | empty |
| 2 | 86 | 0.33 | 0.74 | 14 | empty |
| 3 | 67 | 0.29 | 0.73 | 11 | empty |
Interfaces
6 interfaces between chains.
- A–D · 2499 Ų buried · 27 hydrogen bonds · protein-protein
- B–C · 2397 Ų buried · 19 hydrogen bonds · protein-protein
- B–A · 600 Ų buried · 12 hydrogen bonds · protein-protein
- C–D · 191 Ų buried · 0 hydrogen bonds · protein-protein
- C–A · 47 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 7DA1 · Crystal structure of the chicken MHF complex · the same entry in another collection · chain D against D, TM-score 1.00
- P0DJH7 · AlphaFold monomer V2.0 prediction for centromere protein X (P0DJH7) · a predicted model of the same protein · chain C against A, TM-score 0.95
- E1BSW7 · AlphaFold monomer V2.0 prediction for centromere protein S (E1BSW7) · a predicted model of the same protein · chain B against A, TM-score 0.90
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt E1BSW7
- Every structure of UniProt P0DJH7
- Elsewhere: RCSB PDB 7DA1 · PDBe 7DA1 · UniProt E1BSW7 · UniProt P0DJH7
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