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Structural insights into membrane remodeling by SNX1

Analyse Structural insights into membrane remodeling by SNX1 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 7D6E
Type: protein
Length: 6,840 residues
Chains: 18
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Sorting nexin-1
UniProt: Q6NZD2
Pockets: 20 · best druggability 0.85

Structure

electron microscopy · 1 distinct chain · 69% helix, 6% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R	Sorting nexin-1	protein	380	69% helix, 6% strand	Q6NZD2

Pockets

20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	407	0.85	0.92	52	empty
2	409	0.85	0.92	52	empty
3	392	0.84	0.92	51	empty
4	371	0.84	0.93	42	empty
5	396	0.84	0.92	48	empty

Interfaces

23 interfaces between chains.

Q–R · 1725 Å² buried · 8 hydrogen bonds · protein-protein
C–D · 1724 Å² buried · 8 hydrogen bonds · protein-protein
M–N · 1723 Å² buried · 8 hydrogen bonds · protein-protein
E–F · 1723 Å² buried · 8 hydrogen bonds · protein-protein
A–B · 1722 Å² buried · 8 hydrogen bonds · protein-protein

Compared structures

7D6E · Structural insights into membrane remodeling by SNX1 · the same entry in another collection · chain H against H, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q6NZD2
Elsewhere: RCSB PDB 7D6E · PDBe 7D6E · UniProt Q6NZD2

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