Research workbench
Crystal structure of tRNA (M1G37) methyltransferase from aquifex aeolicus
Analyse Crystal structure of tRNA (M1G37) methyltransferase from aquifex aeolicus in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1OY5
- Type
- protein
- Length
- 654 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- TRNA (guanine-N(1)-)-methyltransferase
- EC
- 2.1.1.31
- UniProt
- O67463
- Pockets
- 5 · best druggability 0.65
Structure
x-ray diffraction · 1 distinct chain · 36% helix, 19% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C | TRNA (guanine-N(1)-)-methyltransferase (EC 2.1.1.31) | protein | 218 | 36% helix, 19% strand | O67463 |
Pockets
5 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 528 | 0.65 | 0.76 | 62 | empty |
| 2 | 108 | 0.65 | 0.89 | 20 | empty |
| 3 | 317 | 0.60 | 0.78 | 37 | empty |
| 4 | 115 | 0.40 | 0.75 | 18 | empty |
| 5 | 56 | 0.26 | 0.73 | 17 | empty |
Interfaces
2 interfaces between chains.
- A–C · 3356 Ų buried · 34 hydrogen bonds · protein-protein
- B–C · 44 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 1OY5 · Crystal structure of tRNA (m1G37) methyltransferase from Aquifex aeolicus · the same entry in another collection · chain A against A, TM-score 1.00
- O67463 · AlphaFold monomer V2.0 prediction for tRNA (guanine-N(1)-)-methyltransferase (O67463) · a predicted model of the same protein · chain A against A, TM-score 0.87
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O67463
- Elsewhere: RCSB PDB 1OY5 · PDBe 1OY5 · UniProt O67463
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