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Crystal structure of OSPHR2 in complex with DNA
Analyse Crystal structure of OSPHR2 in complex with DNA in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7D3T
- Type
- protein + DNA
- Length
- 303 residues
- Chains
- 8
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Protein phosphate starvation response 2; DNA (5'…
- UniProt
- B8B5N8
- Pockets
- 6 · best druggability 0.67
Structure
x-ray diffraction · 4 distinct chains · 59% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C | Protein phosphate starvation response 2 | protein | 59 | 63% helix, 0% strand | B8B5N8 |
| D | Protein phosphate starvation response 2 | protein | 62 | 55% helix, 0% strand | B8B5N8 |
| E, G | DNA (5'- D(P*GP*CP*TP*TP*GP*AP*GP*GP*AP*TP*AP*TP*CP*CP*GP*A)-3') | dna | 16 | — | — |
| F, H | DNA (5'- D(P*CP*TP*CP*GP*GP*AP*TP*AP*TP*CP*CP*TP*CP*AP*AP*G)-3') | dna | 16 | — | — |
Pockets
6 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 277 | 0.67 | 0.83 | 38 | empty |
| 2 | 197 | 0.63 | 0.83 | 30 | empty |
| 3 | 88 | 0.58 | 0.87 | 19 | empty |
| 4 | 83 | 0.41 | 0.79 | 18 | empty |
| 5 | 68 | 0.31 | 0.75 | 13 | empty |
Interfaces
14 interfaces between chains.
- E–F · 700 Ų buried · 59 hydrogen bonds · nucleic-nucleic
- G–H · 693 Ų buried · 55 hydrogen bonds · nucleic-nucleic
- A–F · 507 Ų buried · 7 hydrogen bonds · protein-nucleic
- D–H · 500 Ų buried · 7 hydrogen bonds · protein-nucleic
- C–H · 494 Ų buried · 12 hydrogen bonds · protein-nucleic
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt B8B5N8
- Elsewhere: RCSB PDB 7D3T · PDBe 7D3T · UniProt B8B5N8
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