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The ligand-free structure of human ppargamma lbd R280C mutant

Analyse The ligand-free structure of human ppargamma lbd R280C mutant in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 7CXE
Type: protein
Length: 517 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Peroxisome proliferator-activated receptor gamma
UniProt: P37231
Pockets: 9 · best druggability 0.78

Structure

x-ray diffraction · 2 distinct chains · 67% helix, 5% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Peroxisome proliferator-activated receptor gamma	protein	262	68% helix, 5% strand	P37231
B	Peroxisome proliferator-activated receptor gamma	protein	255	66% helix, 5% strand	P37231

Pockets

9 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	441	0.78	0.86	53	empty
2	383	0.78	0.87	46	empty
3	254	0.60	0.79	27	empty
4	354	0.58	0.76	37	empty
5	111	0.56	0.84	17	empty

Interfaces

1 interface between chains.

A–B · 905 Å² buried · 8 hydrogen bonds · protein-protein

Compared structures

7CXE · The ligand-free structure of human PPARgamma LBD R280C mutant · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P37231
Elsewhere: RCSB PDB 7CXE · PDBe 7CXE · UniProt P37231

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