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Crystal structure of fission yeast POT1 and ssdna

Analyse Crystal structure of fission yeast POT1 and ssdna in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 7CUH
Type: protein + DNA
Length: 323 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Protection of telomeres protein 1; Telomere single-strand DNA
UniProt: O13988
Pockets: 4 · best druggability 0.76

Structure

x-ray diffraction · 2 distinct chains · 17% helix, 37% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Protection of telomeres protein 1	protein	305	17% helix, 37% strand	O13988
B	Telomere single-strand DNA	dna	18	—	—

Pockets

4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	498	0.76	0.84	50	empty
2	51	0.45	0.85	12	empty
3	69	0.43	0.81	22	empty
4	50	0.34	0.78	10	empty

Interfaces

1 interface between chains.

A–B · 1990 Å² buried · 60 hydrogen bonds · protein-nucleic

Compared structures

7CUH · Crystal structure of fission yeast Pot1 and ssDNA · the same entry in another collection · chain A against A, TM-score 1.00
O13988 · AlphaFold monomer V2.0 prediction for protection of telomeres protein 1 (O13988) · a predicted model of the same protein · chain A against A, TM-score 0.54

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O13988
Elsewhere: RCSB PDB 7CUH · PDBe 7CUH · UniProt O13988

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