Research workbench
Crystal structure of the N-terminal tandem rrm domains of RBM45 in complex with single-stranded DNA
Analyse Crystal structure of the N-terminal tandem rrm domains of RBM45 in complex with… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7CSZ
- Type
- protein + DNA
- Length
- 185 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- RNA-binding protein 45; DNA (5'-D(*CP*GP*AP*CP*GP*GP*GP*AP*CP*GP*C)-3')
- UniProt
- Q8IUH3
- Pockets
- 3 · best druggability 0.50
Structure
x-ray diffraction · 3 distinct chains · 28% helix, 29% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | RNA-binding protein 45 | protein | 175 | 28% helix, 29% strand | Q8IUH3 |
| B | DNA (5'-D(*CP*GP*AP*CP*GP*GP*GP*AP*CP*GP*C)-3') | dna | 5 | — | — |
| C | DNA (5'-D(*CP*GP*AP*CP*GP*GP*GP*AP*CP*GP*C)-3') | dna | 5 | — | — |
Pockets
3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 191 | 0.50 | 0.77 | 28 | empty |
| 2 | 76 | 0.38 | 0.77 | 13 | empty |
| 3 | 77 | 0.36 | 0.77 | 17 | empty |
Interfaces
2 interfaces between chains.
- A–B · 733 Ų buried · 17 hydrogen bonds · protein-nucleic
- A–C · 650 Ų buried · 13 hydrogen bonds · protein-nucleic
Compared structures
- 7CSZ · Crystal structure of the N-terminal tandem RRM domains of RBM45 in complex with… · the same entry in another collection · chain A against A, TM-score 1.00
- Q8IUH3 · AlphaFold monomer V2.0 prediction for RNA-binding protein 45 (Q8IUH3) · a predicted model of the same protein · chain A against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8IUH3
- Elsewhere: RCSB PDB 7CSZ · PDBe 7CSZ · UniProt Q8IUH3
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