Research workbench
Apo structure of dimeric IIPLR1
Analyse Apo structure of dimeric IIPLR1 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7CS2
- Type
- protein
- Length
- 1,741 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Pinoresinol-lariciresinol reductase
- UniProt
- I6LRS1
- Pockets
- 20 · best druggability 0.76
Structure
x-ray diffraction · 4 distinct chains · 41% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, E | Pinoresinol-lariciresinol reductase | protein | 298 | 38% helix, 17% strand | I6LRS1 |
| C | Pinoresinol-lariciresinol reductase | protein | 283 | 42% helix, 18% strand | I6LRS1 |
| D | Pinoresinol-lariciresinol reductase | protein | 282 | 42% helix, 18% strand | I6LRS1 |
| F | Pinoresinol-lariciresinol reductase | protein | 282 | 41% helix, 18% strand | I6LRS1 |
Pockets
20 pockets found on a 1 Å grid, 13 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 764 | 0.76 | 0.81 | 60 | empty |
| 2 | 723 | 0.75 | 0.80 | 56 | empty |
| 3 | 801 | 0.75 | 0.79 | 77 | empty |
| 4 | 431 | 0.70 | 0.81 | 60 | empty |
| 5 | 420 | 0.70 | 0.81 | 42 | empty |
Interfaces
8 interfaces between chains.
- E–F · 1199 Ų buried · 13 hydrogen bonds · protein-protein
- B–D · 1197 Ų buried · 17 hydrogen bonds · protein-protein
- A–C · 1190 Ų buried · 12 hydrogen bonds · protein-protein
- B–F · 576 Ų buried · 3 hydrogen bonds · protein-protein
- D–E · 568 Ų buried · 2 hydrogen bonds · protein-protein
Compared structures
- 7CS2 · Apo structure of dimeric IiPLR1 · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt I6LRS1
- Elsewhere: RCSB PDB 7CS2 · PDBe 7CS2 · UniProt I6LRS1
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