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Lovastatin nonaketide synthase

Analyse Lovastatin nonaketide synthase in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 7CPX
Type: protein
Length: 4,524 residues
Chains: 2
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Lovastatin nonaketide synthase, polyketide synthase component
EC: 2.3.1.161
UniProt: Q9Y8A5
Ligands: NAP
Pockets: 20 · best druggability 0.76

Structure

electron microscopy · 1 distinct chain · 36% helix, 21% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Lovastatin nonaketide synthase, polyketide synthase component (EC 2.3.1.161)	protein	2262	36% helix, 21% strand	Q9Y8A5

Ligands and binding sites

NAP · Nadp nicotinamide-adenine-dinucleotide phosphate · ligand · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	733	0.76	0.81	69	empty
2	770	0.74	0.80	70	empty
3	314	0.72	0.85	43	NAP
4	316	0.72	0.85	40	empty
5	304	0.71	0.85	44	NAP

Interfaces

1 interface between chains.

A–B · 6478 Å² buried · 108 hydrogen bonds · protein-protein

Compared structures

7CPX · Lovastatin nonaketide synthase · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9Y8A5
Elsewhere: RCSB PDB 7CPX · PDBe 7CPX · UniProt Q9Y8A5

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