Research workbench
Isocitrate lyase from bacillus cereus atcc 14579
Analyse Isocitrate lyase from bacillus cereus atcc 14579 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7CMX
- Type
- protein
- Length
- 1,687 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Isocitrate lyase
- EC
- 4.1.3.1
- UniProt
- Q81GQ9
- Pockets
- 20 · best druggability 0.91
Structure
x-ray diffraction · 2 distinct chains · 52% helix, 12% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C | Isocitrate lyase (EC 4.1.3.1) | protein | 422 | 52% helix, 12% strand | Q81GQ9 |
| D | Isocitrate lyase (EC 4.1.3.1) | protein | 421 | 53% helix, 12% strand | Q81GQ9 |
Pockets
20 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1036 | 0.91 | 0.94 | 180 | empty |
| 2 | 961 | 0.91 | 0.93 | 163 | empty |
| 3 | 94 | 0.72 | 0.95 | 32 | empty |
| 4 | 89 | 0.70 | 0.94 | 22 | empty |
| 5 | 255 | 0.53 | 0.76 | 25 | empty |
Interfaces
6 interfaces between chains.
- A–B · 5072 Ų buried · 73 hydrogen bonds · protein-protein
- C–D · 5059 Ų buried · 81 hydrogen bonds · protein-protein
- B–C · 2041 Ų buried · 22 hydrogen bonds · protein-protein
- A–D · 1945 Ų buried · 28 hydrogen bonds · protein-protein
- B–D · 999 Ų buried · 10 hydrogen bonds · protein-protein
Compared structures
- 7CMX · Isocitrate lyase from Bacillus cereus ATCC 14579 · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q81GQ9
- Elsewhere: RCSB PDB 7CMX · PDBe 7CMX · UniProt Q81GQ9
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