Research workbench
Crystal structure of homoserine O-succinyltransferase from escherichia COLI K-12
Analyse Crystal structure of homoserine O-succinyltransferase from escherichia COLI K-12 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7CBE
- Type
- protein
- Length
- 575 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Homoserine O-succinyltransferase
- EC
- 2.3.1.46
- UniProt
- P07623
- Ligands
- SO4
- Pockets
- 6 · best druggability 0.64
Structure
x-ray diffraction · 2 distinct chains · 34% helix, 26% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Homoserine O-succinyltransferase (EC 2.3.1.46) | protein | 283 | 34% helix, 26% strand | P07623 |
| B | Homoserine O-succinyltransferase (EC 2.3.1.46) | protein | 292 | 33% helix, 25% strand | P07623 |
Ligands and binding sites
- SO4 · Sulfate ion · ion · 2 copies · chains A, B
- EDO · 1,2-ethanediol · additive · chains A, B
- GOL · Glycerol · additive · chains B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
6 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 187 | 0.64 | 0.85 | 27 | empty |
| 2 | 256 | 0.64 | 0.81 | 39 | GOL |
| 3 | 236 | 0.63 | 0.82 | 39 | empty |
| 4 | 216 | 0.63 | 0.83 | 36 | EDO |
| 5 | 224 | 0.50 | 0.76 | 34 | empty |
Interfaces
1 interface between chains.
- A–B · 2447 Ų buried · 44 hydrogen bonds · protein-protein
Compared structures
- 7CBE · Crystal structure of Homoserine O-succinyltransferase from Escherichia coli K-12 · the same entry in another collection · chain A against A, TM-score 1.00
- P07623 · AlphaFold monomer V2.0 prediction for homoserine O-succinyltransferase (P07623) · a predicted model of the same protein · chain A against A, TM-score 0.89
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P07623
- Elsewhere: RCSB PDB 7CBE · PDBe 7CBE · UniProt P07623
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