Research workbench

CYP76AH1/MILTIRADIENE from salvia miltiorrhiza

Analyse CYP76AH1/MILTIRADIENE from salvia miltiorrhiza in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 7CB9
Type: protein
Length: 466 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Ferruginol synthase
EC: 1.14.13.190
UniProt: S4UX02
Ligands: HEM, J6C
Pockets: 3 · best druggability 0.86

Structure

x-ray diffraction · 1 distinct chain · 57% helix, 9% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Ferruginol synthase (EC 1.14.13.190)	protein	466	57% helix, 9% strand	S4UX02

Ligands and binding sites

HEM · Protoporphyrin IX containing Fe · ligand · chains A
J6C · Miltiradiene · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1124	0.86	0.87	88	HEM, J6C
2	197	0.48	0.75	26	empty
3	93	0.39	0.76	23	empty

Compared structures

7CB9 · CYP76AH1/miltiradiene from Salvia miltiorrhiza · the same entry in another collection · chain A against A, TM-score 1.00
S4UX02 · AlphaFold monomer V2.0 prediction for ferruginol synthase (S4UX02) · a predicted model of the same protein · chain A against A, TM-score 0.96

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt S4UX02
Elsewhere: RCSB PDB 7CB9 · PDBe 7CB9 · UniProt S4UX02

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.