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SARS-cov-2 main protease (mpro) apo structure (space group P212121)

Analyse SARS-cov-2 main protease (mpro) apo structure (space group P212121) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 7CAM
Type: protein
Length: 595 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: 3C-like proteinase
EC: 3.4.22.69
UniProt: P0DTD1
Pockets: 8 · best druggability 0.78

Structure

x-ray diffraction · 2 distinct chains · 26% helix, 29% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	3C-like proteinase (EC 3.4.22.69)	protein	297	26% helix, 29% strand	P0DTD1
B	3C-like proteinase (EC 3.4.22.69)	protein	298	25% helix, 30% strand	P0DTD1

Pockets

8 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	982	0.78	0.80	88	empty
2	349	0.57	0.75	52	empty
3	81	0.45	0.81	15	empty
4	158	0.44	0.75	30	empty
5	122	0.41	0.75	19	empty

Interfaces

1 interface between chains.

A–B · 1059 Å² buried · 20 hydrogen bonds · protein-protein

Compared structures

7CAM · SARS-CoV-2 main protease (Mpro) apo structure (space group P212121) · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P0DTD1
Elsewhere: RCSB PDB 7CAM · PDBe 7CAM · UniProt P0DTD1

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