Research workbench
Cryo-EM structure of mouse TLR3 in complex with UNC93B1
Analyse Cryo-EM structure of mouse TLR3 in complex with UNC93B1 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7C77
- Type
- protein
- Length
- 1,183 residues
- Chains
- 2
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Toll-like receptor 3; Protein unc-93 homolog B1
- UniProt
- Q99MB1, Q8VCW4
- Ligands
- NAG, BMA
- Pockets
- 7 · best druggability 0.86
Structure
electron microscopy · 2 distinct chains · 35% helix, 10% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Toll-like receptor 3 | protein | 700 | 12% helix, 17% strand | Q99MB1 |
| B | Protein unc-93 homolog B1 | protein | 483 | 69% helix, 0% strand | Q8VCW4 |
Ligands and binding sites
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 19 copies · chains A, B
- BMA · beta-D-mannopyranose · sugar
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
7 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 928 | 0.86 | 0.87 | 87 | empty |
| 2 | 58 | 0.67 | 0.96 | 16 | empty |
| 3 | 88 | 0.59 | 0.87 | 21 | empty |
| 4 | 105 | 0.40 | 0.76 | 15 | empty |
| 5 | 67 | 0.39 | 0.78 | 15 | empty |
Interfaces
1 interface between chains.
- A–B · 1456 Ų buried · 3 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 14 glycan, 5 disulfide (N-glycosylation, disulfide).
Compared structures
- 7C77 · Cryo-EM structure of mouse TLR3 in complex with UNC93B1 · the same entry in another collection · chain A against A, TM-score 1.00
- Q8VCW4 · AlphaFold monomer V2.0 prediction for protein unc-93 homolog B1 (Q8VCW4) · a predicted model of the same protein · chain B against A, TM-score 0.98
- Q99MB1 · AlphaFold monomer V2.0 prediction for toll-like receptor 3 (Q99MB1) · a predicted model of the same protein · chain A against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q99MB1
- Every structure of UniProt Q8VCW4
- Elsewhere: RCSB PDB 7C77 · PDBe 7C77 · UniProt Q99MB1 · UniProt Q8VCW4
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