Research workbench
Helical reconstruction of dengue virus serotype 3 complexed with Fab C10
Analyse Helical reconstruction of dengue virus serotype 3 complexed with Fab C10 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7C2S
- Type
- protein
- Length
- 1,260 residues
- Chains
- 6
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Envelope protein; Heavy chain of Fab C10; Light chain of Fab C10
- UniProt
- Q07019
- Pockets
- 12 · best druggability 0.69
Structure
electron microscopy · 3 distinct chains · 0% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Envelope protein | protein | 394 | 0% helix, 0% strand | Q07019 |
| G, I | Heavy chain of Fab C10 | protein | 127 | 0% helix, 0% strand | — |
| H, M | Light chain of Fab C10 | protein | 109 | 0% helix, 0% strand | — |
Pockets
12 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 667 | 0.69 | 0.75 | 105 | empty |
| 2 | 645 | 0.68 | 0.74 | 108 | empty |
| 3 | 284 | 0.53 | 0.73 | 63 | empty |
| 4 | 244 | 0.53 | 0.74 | 50 | empty |
| 5 | 253 | 0.52 | 0.73 | 60 | empty |
Interfaces
6 interfaces between chains.
- A–B · 475 Ų buried · 0 hydrogen bonds · protein-protein
- G–H · 313 Ų buried · 0 hydrogen bonds · protein-protein
- I–M · 245 Ų buried · 0 hydrogen bonds · protein-protein
- B–M · 38 Ų buried · 0 hydrogen bonds · protein-protein
- B–H · 27 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 7C2S · Helical reconstruction of Dengue virus serotype 3 complexed with Fab C10 · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q07019
- Elsewhere: RCSB PDB 7C2S · PDBe 7C2S · UniProt Q07019
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