Research workbench
Crystal structure of ferredoxin: thioredoxin reductase and thioredoxin F2 complex
Analyse Crystal structure of ferredoxin: thioredoxin reductase and thioredoxin F2… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7C2B
- Type
- protein
- Length
- 310 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Ferredoxin-thioredoxin reductase catalytic chain, chloroplastic; Ferredoxin-thioredoxin…
- EC
- 1.8.7.2
- UniProt
- Q9SJ89, Q8LBP6, Q9XFH9
- Ligands
- SF4, MG, NO3
- Pockets
- 4 · best druggability 0.61
Structure
x-ray diffraction · 3 distinct chains · 35% helix, 25% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Ferredoxin-thioredoxin reductase catalytic chain, chloroplastic (EC 1.8.7.2) | protein | 112 | 50% helix, 6% strand | Q9SJ89 |
| B | Ferredoxin-thioredoxin reductase variable chain, chloroplastic | protein | 88 | 11% helix, 45% strand | Q8LBP6 |
| C | Thioredoxin F2, chloroplastic | protein | 110 | 38% helix, 27% strand | Q9XFH9 |
Ligands and binding sites
- SF4 · Iron/sulfur cluster · ligand · chains A
- MG · Magnesium ion · metal · chains C
- NO3 · Nitrate ion · ion · 14 copies · chains A, B, C
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 146 | 0.61 | 0.85 | 21 | NO3 |
| 2 | 172 | 0.42 | 0.73 | 33 | NO3 |
| 3 | 96 | 0.34 | 0.74 | 23 | empty |
| 4 | 51 | 0.30 | 0.76 | 12 | NO3 |
Interfaces
3 interfaces between chains.
- A–B · 779 Ų buried · 11 hydrogen bonds · protein-protein
- A–C · 765 Ų buried · 6 hydrogen bonds · protein-protein
- B–C · 38 Ų buried · 0 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
- 7C2B · Crystal structure of ferredoxin: thioredoxin reductase and thioredoxin f2 complex · the same entry in another collection · chain A against A, TM-score 1.00
- Q9XFH9 · AlphaFold monomer V2.0 prediction for thioredoxin F2, chloroplastic (Q9XFH9) · a predicted model of the same protein · chain C against A, TM-score 0.99
- Q9SJ89 · AlphaFold monomer V2.0 prediction for ferredoxin-thioredoxin reductase catalytic chain… · a predicted model of the same protein · chain A against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9SJ89
- Every structure of UniProt Q8LBP6
- Every structure of UniProt Q9XFH9
- Elsewhere: RCSB PDB 7C2B · PDBe 7C2B · UniProt Q9SJ89 · UniProt Q8LBP6 · UniProt Q9XFH9
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