Research workbench

ACA1 in complex with 14BP palindromic DNA target

Analyse ACA1 in complex with 14BP palindromic DNA target in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 7C0G
Type: protein + DNA
Length: 171 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: ACA1; Palindromic DNA target
UniProt: L7P845
Pockets: 2 · best druggability 0.68

Structure

x-ray diffraction · 3 distinct chains · 59% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	ACA1	protein	72	61% helix, 0% strand	L7P845
B	ACA1	protein	71	58% helix, 0% strand	L7P845
C, D	Palindromic DNA target	dna	14	—	—

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	472	0.68	0.79	42	empty
2	53	0.29	0.75	12	empty

Interfaces

6 interfaces between chains.

A–B · 665 Å² buried · 3 hydrogen bonds · protein-protein
C–D · 659 Å² buried · 57 hydrogen bonds · nucleic-nucleic
B–D · 240 Å² buried · 2 hydrogen bonds · protein-nucleic
B–C · 213 Å² buried · 7 hydrogen bonds · protein-nucleic
A–C · 95 Å² buried · 3 hydrogen bonds · protein-nucleic

Compared structures

7C0G · Aca1 in complex with 14bp palindromic DNA target · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt L7P845
Elsewhere: RCSB PDB 7C0G · PDBe 7C0G · UniProt L7P845

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.