Research workbench
Crystal structure of the aminoglycoside 6'-N-acetyltransferase from enterococcus faecium
Analyse Crystal structure of the aminoglycoside 6'-N-acetyltransferase from… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7BXZ
- Type
- protein
- Length
- 532 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Aminoglycoside 6'-N-acetyltransferase
- UniProt
- Q47764
- Pockets
- 4 · best druggability 0.72
Structure
x-ray diffraction · 3 distinct chains · 30% helix, 30% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Aminoglycoside 6'-N-acetyltransferase | protein | 176 | 30% helix, 31% strand | Q47764 |
| B | Aminoglycoside 6'-N-acetyltransferase | protein | 180 | 32% helix, 30% strand | Q47764 |
| C | Aminoglycoside 6'-N-acetyltransferase | protein | 176 | 29% helix, 31% strand | Q47764 |
Pockets
4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1061 | 0.72 | 0.76 | 85 | empty |
| 2 | 408 | 0.61 | 0.76 | 50 | empty |
| 3 | 112 | 0.46 | 0.79 | 23 | empty |
| 4 | 148 | 0.43 | 0.75 | 25 | empty |
Interfaces
3 interfaces between chains.
- A–B · 1540 Ų buried · 24 hydrogen bonds · protein-protein
- B–C · 688 Ų buried · 7 hydrogen bonds · protein-protein
- A–C · 11 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 7BXZ · Crystal structure of the aminoglycoside 6'-N-acetyltransferase from Enterococcus faecium · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q47764
- Elsewhere: RCSB PDB 7BXZ · PDBe 7BXZ · UniProt Q47764
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