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Crystal structure of ice-binding protein from an antarctic ascomycete, antarctomyces psychrotrophicus.
Analyse Crystal structure of ice-binding protein from an antarctic ascomycete… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7BWX
- Type
- protein
- Length
- 1,218 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Ice-binding protein ISOFORM1A
- UniProt
- A0A2Z6DSM4
- Ligands
- SO4
- Pockets
- 10 · best druggability 0.74
Structure
x-ray diffraction · 1 distinct chain · 13% helix, 42% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E, F | Ice-binding protein ISOFORM1A | protein | 203 | 13% helix, 42% strand | A0A2Z6DSM4 |
Ligands and binding sites
- SO4 · Sulfate ion · ion · 12 copies · chains A, B, C, D, E, F
- GOL · Glycerol · additive · 2 copies · chains D, F
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
10 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 816 | 0.74 | 0.79 | 94 | SO4 |
| 2 | 694 | 0.73 | 0.79 | 80 | SO4 |
| 3 | 334 | 0.66 | 0.81 | 50 | empty |
| 4 | 99 | 0.34 | 0.73 | 21 | empty |
| 5 | 88 | 0.33 | 0.74 | 20 | empty |
Interfaces
7 interfaces between chains.
- D–F · 848 Ų buried · 7 hydrogen bonds · protein-protein
- A–D · 553 Ų buried · 7 hydrogen bonds · protein-protein
- C–D · 547 Ų buried · 6 hydrogen bonds · protein-protein
- A–C · 544 Ų buried · 7 hydrogen bonds · protein-protein
- E–F · 543 Ų buried · 8 hydrogen bonds · protein-protein
Compared structures
- 7BWX · Crystal structure of ice-binding protein from an Antarctic ascomycete, Antarctomyces… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A2Z6DSM4
- Elsewhere: RCSB PDB 7BWX · PDBe 7BWX · UniProt A0A2Z6DSM4
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