Research workbench
Structure of DOTL(656-783)-icms-icmw-lvga-VPDB(461-590) derived from legionella pneumophila
Analyse Structure of DOTL(656-783)-icms-icmw-lvga-VPDB(461-590) derived from legionella… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7BWK
- Type
- protein
- Length
- 1,342 residues
- Chains
- 10
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Icmo (dotl); Icms; Icmw; Hypothetical virulence protein; Pnpla domain-containing protein
- UniProt
- Q5ZYC6, Q5ZYD0, Q5ZS31, Q5ZY48, Q5ZW60
- Pockets
- 20 · best druggability 0.82
Structure
x-ray diffraction · 8 distinct chains · 54% helix, 8% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Icmo (dotl) | protein | 113 | 53% helix, 2% strand | Q5ZYC6 |
| B, G | Icms | protein | 113 | 48% helix, 18% strand | Q5ZYD0 |
| C, H | Icmw | protein | 149 | 71% helix, 0% strand | Q5ZS31 |
| D | Hypothetical virulence protein | protein | 181 | 36% helix, 19% strand | Q5ZY48 |
| E | Pnpla domain-containing protein | protein | 116 | 74% helix, 0% strand | Q5ZW60 |
| F | Icmo (dotl) | protein | 111 | 56% helix, 2% strand | Q5ZYC6 |
| I | Hypothetical virulence protein | protein | 181 | 36% helix, 18% strand | Q5ZY48 |
| J | Pnpla domain-containing protein | protein | 116 | 72% helix, 0% strand | Q5ZW60 |
Pockets
20 pockets found on a 1 Å grid, 10 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1076 | 0.82 | 0.83 | 108 | empty |
| 2 | 406 | 0.77 | 0.86 | 43 | empty |
| 3 | 520 | 0.77 | 0.84 | 61 | empty |
| 4 | 820 | 0.71 | 0.77 | 106 | empty |
| 5 | 544 | 0.71 | 0.80 | 75 | empty |
Interfaces
26 interfaces between chains.
- A–C · 2833 Ų buried · 20 hydrogen bonds · protein-protein
- F–H · 2731 Ų buried · 18 hydrogen bonds · protein-protein
- B–D · 1548 Ų buried · 22 hydrogen bonds · protein-protein
- G–I · 1534 Ų buried · 23 hydrogen bonds · protein-protein
- H–I · 1348 Ų buried · 18 hydrogen bonds · protein-protein
Compared structures
- 7BWK · Structure of DotL(656-783)-IcmS-IcmW-LvgA-VpdB(461-590) derived from Legionella… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q5ZYC6
- Every structure of UniProt Q5ZYD0
- Every structure of UniProt Q5ZS31
- Every structure of UniProt Q5ZY48
- Every structure of UniProt Q5ZW60
- Elsewhere: RCSB PDB 7BWK · PDBe 7BWK · UniProt Q5ZYC6 · UniProt Q5ZYD0 · UniProt Q5ZS31 · UniProt Q5ZY48 · UniProt Q5ZW60
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