Research workbench
Crystal structure of serine acetyltransferase isoform 3 in complex with cysteine from entamoeba histolytica
Analyse Crystal structure of serine acetyltransferase isoform 3 in complex with… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7BW9
- Type
- protein
- Length
- 833 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Serine acetyltransferase 1, putative
- UniProt
- M7WGH7
- Ligands
- CYS
- Pockets
- 12 · best druggability 0.77
Structure
x-ray diffraction · 3 distinct chains · 48% helix, 13% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Serine acetyltransferase 1, putative | protein | 280 | 48% helix, 13% strand | M7WGH7 |
| B | Serine acetyltransferase 1, putative | protein | 276 | 47% helix, 13% strand | M7WGH7 |
| C | Serine acetyltransferase 1, putative | protein | 277 | 47% helix, 13% strand | M7WGH7 |
Ligands and binding sites
- CYS · Cysteine · ligand · 3 copies · chains A, B, C
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
12 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 723 | 0.77 | 0.82 | 78 | empty |
| 2 | 147 | 0.74 | 0.92 | 25 | empty |
| 3 | 103 | 0.68 | 0.91 | 32 | CYS |
| 4 | 111 | 0.65 | 0.90 | 30 | CYS |
| 5 | 97 | 0.65 | 0.90 | 28 | CYS |
Interfaces
3 interfaces between chains.
- A–B · 2286 Ų buried · 35 hydrogen bonds · protein-protein
- A–C · 2112 Ų buried · 32 hydrogen bonds · protein-protein
- B–C · 2070 Ų buried · 24 hydrogen bonds · protein-protein
Compared structures
- 7BW9 · Crystal structure of Serine acetyltransferase isoform 3 in complex with cysteine from… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt M7WGH7
- Elsewhere: RCSB PDB 7BW9 · PDBe 7BW9 · UniProt M7WGH7
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