Research workbench
Crystal structure of sulfonic peroxiredoxin AHP1 in complex with thioredoxin TRX2
Analyse Crystal structure of sulfonic peroxiredoxin AHP1 in complex with thioredoxin… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7BVV
- Type
- protein
- Length
- 278 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Peroxiredoxin AHP1; Thioredoxin-2
- EC
- 1.11.1.15
- UniProt
- P38013, P22803
- Pockets
- 1 · best druggability 0.59
Structure
x-ray diffraction · 2 distinct chains · 32% helix, 28% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Peroxiredoxin AHP1 (EC 1.11.1.15) | protein | 174 | 28% helix, 29% strand | P38013 |
| B | Thioredoxin-2 | protein | 104 | 38% helix, 26% strand | P22803 |
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 348 | 0.59 | 0.76 | 42 | empty |
Interfaces
1 interface between chains.
- A–B · 266 Ų buried · 6 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 modified (oxidation).
Compared structures
- 7BVV · Crystal structure of sulfonic peroxiredoxin Ahp1 in complex with thioredoxin Trx2 · the same entry in another collection · chain A against A, TM-score 1.00
- P22803 · AlphaFold monomer V2.0 prediction for thioredoxin-2 (P22803) · a predicted model of the same protein · chain B against A, TM-score 0.99
- P38013 · AlphaFold monomer V2.0 prediction for peroxiredoxin AHP1 (P38013) · a predicted model of the same protein · chain A against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P38013
- Every structure of UniProt P22803
- Elsewhere: RCSB PDB 7BVV · PDBe 7BVV · UniProt P38013 · UniProt P22803
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