Research workbench
Atrial natriuretic peptide receptor complexed with deletion mutant of human atrial natriuretic PEPTIDE[5-27]
Analyse Atrial natriuretic peptide receptor complexed with deletion mutant of human… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7BRK
- Type
- protein
- Length
- 875 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Atrial natriuretic peptide receptor 1; Natriuretic peptides a
- EC
- 4.6.1.2
- UniProt
- P18910, P01160
- Ligands
- NAG, MAN, CL
- Pockets
- 8 · best druggability 0.77
Structure
x-ray diffraction · 2 distinct chains · 37% helix, 19% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Atrial natriuretic peptide receptor 1 (EC 4.6.1.2) | protein | 426 | 39% helix, 19% strand | P18910 |
| L | Natriuretic peptides a | protein | 23 | 13% helix, 4% strand | P01160 |
Ligands and binding sites
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 8 copies · chains A, B
- MAN · alpha-D-mannopyranose · sugar · 6 copies · chains A, B
- CL · Chloride ion · ion · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
8 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 994 | 0.77 | 0.80 | 115 | empty |
| 2 | 328 | 0.66 | 0.81 | 45 | empty |
| 3 | 81 | 0.60 | 0.89 | 21 | empty |
| 4 | 80 | 0.59 | 0.88 | 23 | empty |
| 5 | 330 | 0.52 | 0.74 | 44 | empty |
Interfaces
3 interfaces between chains.
- B–L · 1021 Ų buried · 9 hydrogen bonds · protein-protein
- A–L · 739 Ų buried · 7 hydrogen bonds · protein-protein
- A–B · 554 Ų buried · 5 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 5 disulfide, 4 glycan (disulfide, N-glycosylation).
Compared structures
- 7BRK · Atrial Natriuretic Peptide Receptor complexed with deletion mutant of human Atrial… · the same entry in another collection · chain A against A, TM-score 1.00
- P18910 · AlphaFold monomer V2.0 prediction for atrial natriuretic peptide receptor 1 (P18910) · a predicted model of the same protein · chain B against A, TM-score 0.99
- P01160 · AlphaFold monomer V2.0 prediction for natriuretic peptides a (P01160) · a predicted model of the same protein · chain L against A, TM-score 0.17
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P18910
- Every structure of UniProt P01160
- Elsewhere: RCSB PDB 7BRK · PDBe 7BRK · UniProt P18910 · UniProt P01160
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