Research workbench
Structure of the ankyrin domain of the drosophila notch receptor
Analyse Structure of the ankyrin domain of the drosophila notch receptor in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1OT8
- Type
- protein
- Length
- 605 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Neurogenic locus notch protein
- UniProt
- P07207
- Ligands
- MG
- Pockets
- 3 · best druggability 0.75
Structure
x-ray diffraction · 3 distinct chains · 52% helix, 1% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Neurogenic locus notch protein | protein | 209 | 54% helix, 1% strand | P07207 |
| B | Neurogenic locus notch protein | protein | 204 | 52% helix, 1% strand | P07207 |
| C | Neurogenic locus notch protein | protein | 192 | 49% helix, 1% strand | P07207 |
Ligands and binding sites
- MG · Magnesium ion · metal · 3 copies · chains A, C, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1109 | 0.75 | 0.78 | 113 | MG |
| 2 | 444 | 0.63 | 0.77 | 42 | empty |
| 3 | 134 | 0.41 | 0.74 | 19 | empty |
Interfaces
2 interfaces between chains.
- B–C · 828 Ų buried · 22 hydrogen bonds · protein-protein
- A–C · 819 Ų buried · 24 hydrogen bonds · protein-protein
Compared structures
- 1OT8 · Structure of the Ankyrin Domain of the Drosophila Notch Receptor · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P07207
- Elsewhere: RCSB PDB 1OT8 · PDBe 1OT8 · UniProt P07207
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