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Cryo-EM structure of the human MCT2

Analyse Cryo-EM structure of the human MCT2 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 7BP3
Type: protein
Length: 788 residues
Chains: 2
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Monocarboxylate transporter 2
UniProt: O60669
Pockets: 11 · best druggability 0.77

Structure

electron microscopy · 1 distinct chain · 78% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Monocarboxylate transporter 2	protein	394	78% helix, 0% strand	O60669

Pockets

11 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	101	0.77	0.97	26	empty
2	300	0.76	0.87	50	empty
3	350	0.75	0.86	58	empty
4	57	0.66	0.95	19	empty
5	55	0.65	0.94	18	empty

Interfaces

1 interface between chains.

A–B · 2601 Å² buried · 19 hydrogen bonds · protein-protein

Compared structures

7BP3 · Cryo-EM structure of the human MCT2 · the same entry in another collection · chain A against A, TM-score 1.00
O60669 · AlphaFold monomer V2.0 prediction for monocarboxylate transporter 2 (O60669) · a predicted model of the same protein · chain A against A, TM-score 0.94

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O60669
Elsewhere: RCSB PDB 7BP3 · PDBe 7BP3 · UniProt O60669

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