Research workbench
MHC class I H-2KB heavy chain complexed with beta-2 microglobulin and an (L4V) mutant of the vesicular stomatitis virus nucleoprotein
Analyse MHC class I H-2KB heavy chain complexed with beta-2 microglobulin and an (L4V)… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1OSZ
- Type
- protein
- Length
- 381 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- MHC class I H-2KB heavy chain; Beta-2 microglobulin; Vesicular stomatitis virus…
- UniProt
- P01901, P01887
- Pockets
- 5 · best druggability 0.61
Structure
x-ray diffraction · 3 distinct chains · 20% helix, 42% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | MHC class I H-2KB heavy chain | protein | 274 | 28% helix, 39% strand | P01901 |
| B | Beta-2 microglobulin | protein | 99 | 0% helix, 55% strand | P01887 |
| C | Vesicular stomatitis virus nucleoprotein | protein | 8 | 0% helix, 0% strand | — |
Pockets
5 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 259 | 0.61 | 0.80 | 34 | empty |
| 2 | 346 | 0.58 | 0.76 | 46 | empty |
| 3 | 67 | 0.55 | 0.88 | 18 | empty |
| 4 | 131 | 0.49 | 0.79 | 23 | empty |
| 5 | 82 | 0.37 | 0.76 | 17 | empty |
Interfaces
2 interfaces between chains.
- A–B · 1295 Ų buried · 23 hydrogen bonds · protein-protein
- A–C · 943 Ų buried · 25 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 3 disulfide (disulfide).
Compared structures
- 1OSZ · MHC class I H-2KB heavy chain complexed with beta-2 microglobulin and an (L4V) mutant of… · the same entry in another collection · chain A against A, TM-score 1.00
- P01887 · AlphaFold monomer V2.0 prediction for beta-2-microglobulin (P01887) · a predicted model of the same protein · chain B against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P01901
- Every structure of UniProt P01887
- Elsewhere: RCSB PDB 1OSZ · PDBe 1OSZ · UniProt P01901 · UniProt P01887
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