Research workbench
Crystal structure of outer surface protein a of borrelia burgdorferi complexed with a murine monoclonal antibody Fab
Analyse Crystal structure of outer surface protein a of borrelia burgdorferi complexed… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1OSP
- Type
- protein
- Length
- 683 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Fab 184.1; Outer surface protein a
- UniProt
- P01867, P14013
- Pockets
- 11 · best druggability 0.55
Structure
x-ray diffraction · 3 distinct chains · 6% helix, 52% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| L | Fab 184.1 | protein | 214 | 6% helix, 48% strand | — |
| H | Fab 184.1 | protein | 218 | 6% helix, 53% strand | P01867 |
| O | Outer surface protein a | protein | 251 | 7% helix, 53% strand | P14013 |
Pockets
11 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 77 | 0.55 | 0.87 | 25 | empty |
| 2 | 318 | 0.54 | 0.75 | 47 | empty |
| 3 | 85 | 0.53 | 0.84 | 18 | empty |
| 4 | 120 | 0.43 | 0.77 | 29 | empty |
| 5 | 112 | 0.40 | 0.76 | 25 | empty |
Interfaces
3 interfaces between chains.
- L–H · 1781 Ų buried · 17 hydrogen bonds · protein-protein
- H–O · 451 Ų buried · 7 hydrogen bonds · protein-protein
- L–O · 378 Ų buried · 5 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 disulfide (disulfide).
Compared structures
- 1OSP · Crystal structure of outer surface protein a of borrelia burgdorferi complexed with a… · the same entry in another collection · chain L against L, TM-score 1.00
- P01867 · AlphaFold monomer V2.0 prediction for ig gamma-2B chain C region (P01867) · a predicted model of the same protein · chain H against A, TM-score 0.50
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P01867
- Every structure of UniProt P14013
- Elsewhere: RCSB PDB 1OSP · PDBe 1OSP · UniProt P01867 · UniProt P14013
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