Research workbench
Solution structure of a dimeric lactose DNA-binding domain complexed to a nonspecific DNA sequence
Analyse Solution structure of a dimeric lactose DNA-binding domain complexed to a… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1OSL
- Type
- protein + DNA
- Length
- 160 residues
- Chains
- 4
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- 5'-D(*CP*GP*AP*TP*AP*AP*GP*AP*TP*AP*TP*CP*TP*TP*AP*TP*CP*G) -3'; Lactose operon repressor
- UniProt
- P03023
- Pockets
- 4 · best druggability 0.61
Structure
solution nmr · 2 distinct chains · 48% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| C, D | 5'-D(*CP*GP*AP*TP*AP*AP*GP*AP*TP*AP*TP*CP*TP*TP*AP*TP*CP*G) -3' | dna | 18 | — | — |
| A, B | Lactose operon repressor | protein | 62 | 48% helix, 0% strand | P03023 |
Pockets
4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 183 | 0.61 | 0.83 | 27 | empty |
| 2 | 99 | 0.54 | 0.84 | 18 | empty |
| 3 | 195 | 0.50 | 0.77 | 23 | empty |
| 4 | 78 | 0.35 | 0.76 | 13 | empty |
Interfaces
6 interfaces between chains.
- C–D · 773 Ų buried · 49 hydrogen bonds · nucleic-nucleic
- C–A · 643 Ų buried · 20 hydrogen bonds · protein-nucleic
- D–A · 525 Ų buried · 10 hydrogen bonds · protein-nucleic
- D–B · 479 Ų buried · 15 hydrogen bonds · protein-nucleic
- C–B · 457 Ų buried · 11 hydrogen bonds · protein-nucleic
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
- 1OSL · Solution structure of a dimeric lactose DNA-binding domain complexed to a nonspecific DNA… · the same entry in another collection · chain C against C, TM-score 1.00
- P03023 · AlphaFold monomer V2.0 prediction for lactose operon repressor (P03023) · a predicted model of the same protein · chain A against A, TM-score 0.70
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P03023
- Elsewhere: RCSB PDB 1OSL · PDBe 1OSL · UniProt P03023
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