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Crystal structure of the N-terminal dimeric coiled coil of the human ctip protein

Analyse Crystal structure of the N-terminal dimeric coiled coil of the human ctip… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 7BGF
Type: protein
Length: 220 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: DNA endonuclease RBBP8,CTIP/RBBP8
EC: 3.1.-.-
UniProt: Q99708
Pockets: 1 · best druggability 0.39

Structure

x-ray diffraction · 2 distinct chains · 98% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	DNA endonuclease RBBP8,CTIP/RBBP8 (EC 3.1.-.-)	protein	112	98% helix, 0% strand	Q99708
B	DNA endonuclease RBBP8,CTIP/RBBP8 (EC 3.1.-.-)	protein	108	98% helix, 0% strand	Q99708

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	61	0.39	0.80	17	empty

Interfaces

1 interface between chains.

A–B · 2903 Å² buried · 16 hydrogen bonds · protein-protein

Compared structures

7BGF · Crystal structure of the N-terminal dimeric coiled coil of the human ctip protein · the same entry in another collection · chain A against A, TM-score 1.00
Q99708 · AlphaFold monomer V2.0 prediction for DNA endonuclease RBBP8 (Q99708) · a predicted model of the same protein · chain B against A, TM-score 0.66

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q99708
Elsewhere: RCSB PDB 7BGF · PDBe 7BGF · UniProt Q99708

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