Research workbench
HRV14 native particle solved by cryoem
Analyse HRV14 native particle solved by cryoem in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7BG6
- Type
- protein + RNA
- Length
- 813 residues
- Chains
- 5
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- RNA-octamer (5'-R(P*UP*GP*UP*UP*UP*UP*UP*A)-3'); Genome polyprotein
- EC
- 3.4.22.29, 3.6.1.15, 3.4.22.28, 2.7.7.48
- UniProt
- P03303
- Pockets
- 12 · best druggability 0.77
Structure
electron microscopy · 5 distinct chains · 10% helix, 33% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| C | RNA-octamer (5'-R(P*UP*GP*UP*UP*UP*UP*UP*A)-3') | rna | 8 | — | — |
| 1 | Genome polyprotein (EC 3.4.22.29, 3.6.1.15, 3.4.22.28, 2.7.7.48) | protein | 273 | 10% helix, 33% strand | P03303 |
| 2 | Genome polyprotein (EC 3.4.22.29, 3.6.1.15, 3.4.22.28, 2.7.7.48) | protein | 256 | 12% helix, 38% strand | P03303 |
| 3 | Genome polyprotein (EC 3.4.22.29, 3.6.1.15, 3.4.22.28, 2.7.7.48) | protein | 236 | 9% helix, 33% strand | P03303 |
| 4 | Genome polyprotein (EC 3.4.22.29, 3.6.1.15, 3.4.22.28, 2.7.7.48) | protein | 40 | 10% helix, 3% strand | P03303 |
Pockets
12 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 135 | 0.77 | 0.95 | 26 | empty |
| 2 | 156 | 0.48 | 0.77 | 29 | empty |
| 3 | 170 | 0.47 | 0.76 | 34 | empty |
| 4 | 61 | 0.46 | 0.83 | 15 | empty |
| 5 | 106 | 0.42 | 0.77 | 24 | empty |
Interfaces
8 interfaces between chains.
- 1–3 · 4207 Ų buried · 83 hydrogen bonds · protein-protein
- 1–2 · 2083 Ų buried · 43 hydrogen bonds · protein-protein
- 2–3 · 1670 Ų buried · 17 hydrogen bonds · protein-protein
- 1–4 · 968 Ų buried · 15 hydrogen bonds · protein-protein
- 3–4 · 861 Ų buried · 16 hydrogen bonds · protein-protein
Compared structures
- 7BG6 · HRV14 native particle solved by cryoEM · the same entry in another collection · chain C against C, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P03303
- Elsewhere: RCSB PDB 7BG6 · PDBe 7BG6 · UniProt P03303
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