Research workbench
VAR2CSA full ectodomain in present of plcs, DBL1-DBL4
Analyse VAR2CSA full ectodomain in present of plcs, DBL1-DBL4 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7B54
- Type
- protein
- Length
- 1,732 residues
- Chains
- 1
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- VAR2CSA in presence of plcs, DBL1-DBL4,ERYTHROCYTE membrane protein 1
- UniProt
- Q6UDW7
- Pockets
- 20 · best druggability 0.83
Structure
electron microscopy · 1 distinct chain · 47% helix, 2% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| X | VAR2CSA in presence of plcs, DBL1-DBL4,ERYTHROCYTE membrane protein 1 | protein | 1732 | 47% helix, 2% strand | Q6UDW7 |
Pockets
20 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1016 | 0.83 | 0.84 | 96 | empty |
| 2 | 947 | 0.82 | 0.84 | 102 | empty |
| 3 | 1009 | 0.78 | 0.80 | 85 | empty |
| 4 | 1066 | 0.75 | 0.78 | 85 | empty |
| 5 | 314 | 0.67 | 0.82 | 32 | empty |
Modifications
Observed in the structure: 26 disulfide (disulfide).
Compared structures
- 7B54 · VAR2CSA full ectodomain in present of plCS, DBL1-DBL4 · the same entry in another collection · chain X against X, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q6UDW7
- Elsewhere: RCSB PDB 7B54 · PDBe 7B54 · UniProt Q6UDW7
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