Research workbench
Crystal structure of the human CCR4-CAF1 complex
Analyse Crystal structure of the human CCR4-CAF1 complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7AX1
- Type
- protein
- Length
- 771 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- CCR4-not transcription complex subunit 6; CCR4-not transcription complex subunit 7
- EC
- 3.1.13.4
- UniProt
- Q9ULM6, Q9UIV1
- Ligands
- MG
- Pockets
- 11 · best druggability 0.59
Structure
x-ray diffraction · 2 distinct chains · 34% helix, 19% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | CCR4-not transcription complex subunit 6 (EC 3.1.13.4) | protein | 518 | 28% helix, 20% strand | Q9ULM6 |
| B | CCR4-not transcription complex subunit 7 (EC 3.1.13.4) | protein | 253 | 47% helix, 16% strand | Q9UIV1 |
Ligands and binding sites
- MG · Magnesium ion · metal · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
11 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 272 | 0.59 | 0.79 | 44 | MG |
| 2 | 195 | 0.53 | 0.78 | 19 | empty |
| 3 | 206 | 0.49 | 0.76 | 24 | empty |
| 4 | 129 | 0.44 | 0.76 | 19 | empty |
| 5 | 150 | 0.43 | 0.75 | 18 | MG |
Interfaces
1 interface between chains.
- A–B · 1334 Ų buried · 23 hydrogen bonds · protein-protein
Compared structures
- 7AX1 · Crystal structure of the human CCR4-CAF1 complex · the same entry in another collection · chain A against A, TM-score 1.00
- Q9UIV1 · AlphaFold monomer V2.0 prediction for CCR4-not transcription complex subunit 7 (Q9UIV1) · a predicted model of the same protein · chain B against A, TM-score 0.98
- Q9ULM6 · AlphaFold monomer V2.0 prediction for CCR4-not transcription complex subunit 6 (Q9ULM6) · a predicted model of the same protein · chain A against A, TM-score 0.69
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9ULM6
- Every structure of UniProt Q9UIV1
- Elsewhere: RCSB PDB 7AX1 · PDBe 7AX1 · UniProt Q9ULM6 · UniProt Q9UIV1
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