Research workbench
Model of the actin filament ARP2/3 complex branch junction in cells
Analyse Model of the actin filament ARP2/3 complex branch junction in cells in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7AQK
- Type
- protein
- Length
- 6,001 residues
- Chains
- 18
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Actin-related protein 2, ARP2; Actin-related protein 3, ARP3; Actin-related protein 2/3…
- Pockets
- 20 · best druggability 0.73
Structure
electron microscopy · 8 distinct chains · 35% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| b | Actin-related protein 2, ARP2 | protein | 387 | 36% helix, 18% strand | — |
| a | Actin-related protein 3, ARP3 | protein | 418 | 37% helix, 16% strand | — |
| c | Actin-related protein 2/3 complex subunit 1B, ARPC1B | protein | 372 | 5% helix, 41% strand | — |
| d | Actin-related protein 2/3 complex subunit 2, ARPC2 | protein | 281 | 41% helix, 17% strand | — |
| e | Actin-related protein 2/3 complex subunit 3, ARPC3 | protein | 178 | 44% helix, 3% strand | — |
| f | Actin-related protein 2/3 complex subunit 4, ARPC4 | protein | 168 | 42% helix, 14% strand | — |
| g | Actin-related protein 2/3 complex subunit 5, ARPC5 | protein | 116 | 72% helix, 0% strand | — |
| h, i, j, k, l, m, n, o, p, q, r | Actin, alpha skeletal muscle, ACTA1 | protein | 371 | 38% helix, 13% strand | — |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1097 | 0.73 | 0.77 | 141 | empty |
| 2 | 828 | 0.72 | 0.78 | 100 | empty |
| 3 | 876 | 0.71 | 0.77 | 105 | empty |
| 4 | 906 | 0.71 | 0.77 | 124 | empty |
| 5 | 1071 | 0.67 | 0.74 | 116 | empty |
Interfaces
35 interfaces between chains.
- c–f · 283 Ų buried · 7 hydrogen bonds · protein-protein
- f–g · 259 Ų buried · 5 hydrogen bonds · protein-protein
- a–d · 242 Ų buried · 6 hydrogen bonds · protein-protein
- a–h · 217 Ų buried · 5 hydrogen bonds · protein-protein
- h–i · 196 Ų buried · 3 hydrogen bonds · protein-protein
Compared structures
- 7AQK · Model of the actin filament Arp2/3 complex branch junction in cells · the same entry in another collection · chain b against b, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 7AQK · PDBe 7AQK
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