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OPG2 Fab fragment

Analyse OPG2 Fab fragment in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1OPG
Type: protein
Length: 441 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: OPG2 Fab (light chain); OPG2 Fab (heavy chain)
UniProt: P01868
Pockets: 5 · best druggability 0.58

Structure

x-ray diffraction · 2 distinct chains · 6% helix, 49% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
L	OPG2 Fab (light chain)	protein	214	6% helix, 50% strand	—
H	OPG2 Fab (heavy chain)	protein	227	5% helix, 48% strand	P01868

Pockets

5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	406	0.58	0.75	48	empty
2	248	0.53	0.76	38	empty
3	130	0.49	0.79	23	empty
4	91	0.34	0.74	18	empty
5	50	0.26	0.73	14	empty

Interfaces

1 interface between chains.

L–H · 1749 Å² buried · 9 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 4 disulfide (disulfide).

Compared structures

1OPG · OPG2 Fab fragment · the same entry in another collection · chain L against L, TM-score 1.00
P01868 · AlphaFold monomer V2.0 prediction for ig gamma-1 chain C region secreted form (P01868) · a predicted model of the same protein · chain H against A, TM-score 0.50

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P01868
Elsewhere: RCSB PDB 1OPG · PDBe 1OPG · UniProt P01868

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