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Structure of luxr with DNA (repression)
Analyse Structure of luxr with DNA (repression) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7AMN
- Type
- protein + DNA
- Length
- 417 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Hth-type transcriptional regulator luxr; DNA (5'…
- UniProt
- B4X9Q4
- Pockets
- 6 · best druggability 0.80
Structure
x-ray diffraction · 4 distinct chains · 73% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| B | Hth-type transcriptional regulator luxr | protein | 186 | 73% helix, 0% strand | B4X9Q4 |
| A | Hth-type transcriptional regulator luxr | protein | 189 | 72% helix, 0% strand | B4X9Q4 |
| E | DNA (5'- D(P*TP*AP*TP*TP*GP*AP*TP*AP*AP*AP*AP*TP*TP*AP*TP*CP*AP*AP*TP*AP*A)- 3') | dna | 21 | — | — |
| F | DNA (5'- D(P*TP*TP*AP*TP*TP*GP*AP*TP*AP*AP*TP*TP*TP*TP*AP*TP*CP*AP*AP*TP*A)- 3') | dna | 21 | — | — |
Pockets
6 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 191 | 0.80 | 0.94 | 30 | empty |
| 2 | 126 | 0.77 | 0.95 | 23 | empty |
| 3 | 75 | 0.72 | 0.96 | 22 | empty |
| 4 | 71 | 0.61 | 0.90 | 17 | empty |
| 5 | 174 | 0.57 | 0.81 | 38 | empty |
Interfaces
6 interfaces between chains.
- B–A · 1953 Ų buried · 26 hydrogen bonds · protein-protein
- E–F · 922 Ų buried · 91 hydrogen bonds · nucleic-nucleic
- A–F · 521 Ų buried · 18 hydrogen bonds · protein-nucleic
- B–E · 521 Ų buried · 15 hydrogen bonds · protein-nucleic
- A–E · 503 Ų buried · 5 hydrogen bonds · protein-nucleic
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
- 7AMN · Structure of LuxR with DNA (repression) · the same entry in another collection · chain B against B, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt B4X9Q4
- Elsewhere: RCSB PDB 7AMN · PDBe 7AMN · UniProt B4X9Q4
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