Research workbench

Structure of salmonella TACT2 toxin bound to TACA2 antitoxin

Analyse Structure of salmonella TACT2 toxin bound to TACA2 antitoxin in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 7AK7
Type: protein
Length: 625 residues
Chains: 6
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Acetyltransferase; Copg family transcriptional regulator
UniProt: A0A0D6HSU7, A0A0D6HUM3
Ligands: ACO, CL
Pockets: 8 · best druggability 0.76

Structure

x-ray diffraction · 6 distinct chains · 51% helix, 20% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Acetyltransferase	protein	154	36% helix, 31% strand	A0A0D6HSU7
B	Acetyltransferase	protein	154	36% helix, 31% strand	A0A0D6HSU7
C	Copg family transcriptional regulator	protein	87	63% helix, 11% strand	A0A0D6HUM3
D	Copg family transcriptional regulator	protein	86	60% helix, 12% strand	A0A0D6HUM3
E	Copg family transcriptional regulator	protein	71	70% helix, 8% strand	A0A0D6HUM3
F	Copg family transcriptional regulator	protein	73	68% helix, 8% strand	A0A0D6HUM3

Ligands and binding sites

ACO · Acetyl coenzyme *A · ligand · 2 copies · chains A, C, B, D
CL · Chloride ion · ion · chains C

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

8 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	577	0.76	0.83	84	empty
2	205	0.62	0.82	27	ACO
3	204	0.60	0.81	27	ACO
4	190	0.59	0.81	22	empty
5	193	0.56	0.80	26	empty

Interfaces

15 interfaces between chains.

A–C · 2274 Å² buried · 30 hydrogen bonds · protein-protein
B–D · 2165 Å² buried · 29 hydrogen bonds · protein-protein
C–F · 1936 Å² buried · 18 hydrogen bonds · protein-protein
D–E · 1835 Å² buried · 22 hydrogen bonds · protein-protein
A–E · 902 Å² buried · 9 hydrogen bonds · protein-protein

Compared structures

7AK7 · Structure of Salmonella TacT2 toxin bound to TacA2 antitoxin · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt A0A0D6HSU7
Every structure of UniProt A0A0D6HUM3
Elsewhere: RCSB PDB 7AK7 · PDBe 7AK7 · UniProt A0A0D6HSU7 · UniProt A0A0D6HUM3

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.