Research workbench
Muts in scanning state
Analyse Muts in scanning state in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7AI5
- Type
- protein + DNA
- Length
- 1,620 residues
- Chains
- 4
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- DNA mismatch repair protein muts; DNA (5'- D(P*CP*TP*AP*TP*AP*GP*GP*GP*CP*GP*AP*AP*TP*TP*G…
- UniProt
- A0A037YGY1
- Ligands
- ATP
- Pockets
- 20 · best druggability 0.76
Structure
electron microscopy · 3 distinct chains · 44% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | DNA mismatch repair protein muts | protein | 788 | 44% helix, 18% strand | A0A037YGY1 |
| C | DNA (5'- D(P*CP*TP*AP*TP*AP*GP*GP*GP*CP*GP*AP*AP*TP*TP*GP*GP*GP*TP*AP*CP*CP*G) -3') | dna | 22 | — | — |
| D | DNA (5'- D(P*CP*GP*GP*TP*AP*CP*CP*CP*AP*AP*TP*TP*CP*GP*CP*CP*CP*TP*AP*TP*AP*G) -3') | dna | 22 | — | — |
Ligands and binding sites
- ATP · Adenosine-5'-triphosphate · ligand · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 11 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 880 | 0.76 | 0.79 | 78 | empty |
| 2 | 811 | 0.74 | 0.79 | 70 | empty |
| 3 | 552 | 0.68 | 0.78 | 45 | empty |
| 4 | 521 | 0.63 | 0.76 | 40 | empty |
| 5 | 483 | 0.62 | 0.76 | 37 | empty |
Interfaces
5 interfaces between chains.
- A–B · 2379 Ų buried · 12 hydrogen bonds · protein-protein
- C–D · 1130 Ų buried · 107 hydrogen bonds · nucleic-nucleic
- B–C · 537 Ų buried · 12 hydrogen bonds · protein-nucleic
- A–D · 395 Ų buried · 5 hydrogen bonds · protein-nucleic
- A–C · 38 Ų buried · 0 hydrogen bonds · protein-nucleic
Compared structures
- 7AI5 · MutS in Scanning state · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A037YGY1
- Elsewhere: RCSB PDB 7AI5 · PDBe 7AI5 · UniProt A0A037YGY1
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