Research workbench
Crystal structure of the KLC1-tpr domain truncated from its nontpr region ([A1-B6]-delta-nontpr fragment)
Analyse Crystal structure of the KLC1-tpr domain truncated from its nontpr region… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7AI4
- Type
- protein
- Length
- 478 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Isoform C of kinesin light chain 1,ISOFORM C of kinesin light chain 1
- UniProt
- Q07866
- Pockets
- 3 · best druggability 0.49
Structure
x-ray diffraction · 2 distinct chains · 81% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Isoform C of kinesin light chain 1,ISOFORM C of kinesin light chain 1 | protein | 243 | 82% helix, 0% strand | Q07866 |
| B | Isoform C of kinesin light chain 1,ISOFORM C of kinesin light chain 1 | protein | 235 | 80% helix, 0% strand | Q07866 |
Pockets
3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 178 | 0.49 | 0.77 | 28 | empty |
| 2 | 69 | 0.39 | 0.79 | 15 | empty |
| 3 | 67 | 0.35 | 0.77 | 13 | empty |
Interfaces
1 interface between chains.
- A–B · 698 Ų buried · 6 hydrogen bonds · protein-protein
Compared structures
- 7AI4 · Crystal structure of the KLC1-TPR domain truncated from its nonTPR region… · the same entry in another collection · chain A against A, TM-score 1.00
- Q07866 · AlphaFold monomer V2.0 prediction for kinesin light chain 1 (Q07866) · a predicted model of the same protein · chain A against A, TM-score 0.86
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q07866
- Elsewhere: RCSB PDB 7AI4 · PDBe 7AI4 · UniProt Q07866
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